XPS

XPS Logo 2015

Cutting-Edge Particle Simulation Software for  Pharmaceutical Applications

ABOUT US

More about XPS

XPS is a high-performance simulation environment for granular flows in industry relevant settings.

It enables the user to understand, control and predict pharmaceutical unit operations leading to enhanced efficiency and improved product quality. Following the golden batch principle, it is possible to minimize the need for physical prototyping and testing.

PARTNERSHIP

RCPE-IST Cooperation

The Research Center Pharmaceutical Engineering (RCPE) and InSilicoTrials (IST) have agreed to an exclusive partnership to commercialize the XPS simulation software. Specifically developed for pharmaceutical applications, XPS allows companies to assess their process configurations in unprecedented detail and explore the decision space without time- and labor-intensive experiments. While RCPE is responsible for the development, IST handles the software solutions worldwide distribution and first-level support

SERVICES

What do we offer?

XPS Software package  (DEM/DEM-CFD/Cloud)

Training

Technical support

Consulting engineering

BENEFITS

What makes XPS
stand out?

XPS is more than a software: the experienced engineering and development team support our customers, offering customized solutions and ensuring maximum software usability.

The Benefits of using the new, coupled software can be summarized as follows:

  • The coupled software allows faster product and process development, because simulation is faster, safer and, moreover, cheaper than experiments.
  • The computational expense for large amounts of particles is low, thanks to the GPU-based massive parallel architecture.
  • Effective CFD-DEM coupling, with options for user-specified functions and multiple modules on the CFD side.
  • In-built GUI for live-viewing and monitoring simulations, capturing images, videos and statistics.

INDUSTRIES

Who do we target?

Prediction and understanding of fluid-granular flow is necessary for many industries

Pharmaceutical 

University & Academia

Food Processing 

Equipment Manufacturer

APPLICATIONS

Understand, Control
and Predict

It is estimated that more than 70% of products in industry are manufactured as particulate solids. Being able to understand, control and predict these granular flows is required in a wide range of unit operations in the pharmaceutical, chemical, food or agriculture industry. Besides many more, typical applications include:

USE CASES

XPS Use Cases

Table Coating

Tablet coating is a common unit operation in the pharmaceutical industry. It is of particular importance since it usually marks the last manufacturing step before the tablets are packaged and made available to patients. XPS enables the process simulation including various tablet shapes and complex device geometries. In addition XPS holds a variety of physical models in order to predict, e.g., spray drying and coating distribution based on the nozzle characteristics. The typical output of these analysis include the coefficient of variations (CoV), spray losses and cycle time and force distributions which can be related to chipping and twinning.

Blending

Blending is a widely-used process during the production of solid oral dosage forms. But especially for cohesive powders, achieving a homogeneous blend can turn into a delicate task with little degrees to freedom to operate on. XPS helps to understand the behavior of granular materials in the mixing process. Among others, charging scenarios can be optimized and the influence of batch mass and operating conditions on the blend homogeneity can be studied. This leads more economic processes including a reduced risk of over-blending.

Fluidized Bed

Fluidized beds are used for spray-drying or mixing. Since several phases are involved (i.e. granular matter, gas, fluid), this processes tend to be challenging. Using a hybrid CPD-GPU CFD-DEM approach, XPS can be coupled with the CFD solver AVL FIRETM. The two-way coupling offers a wide variety of analysis options, e.g. coating, mixing, temperature.

TECHNICAL DETAILS

Architecture Specifications

  • Optimized to drastically reduce the computational demand per time-step and the memory consumption
  • No need for a professional equipment: it works with an ordinary workstation (up to 4 GPUs, one simulation per GPU)
  • Multiple platforms supported (MS Windows, Linux, Cloud)
  • Native CUDA code (Nvidia GPU required)
  • DEM/CFD coupling: reduced transferred data amount between the DEM and the CFD codes, which depends only on the number of the DEM cells and not on the number of particles
  • The two codes run on separated computing platforms (CPUs and GPUs): the computing performance of each code is not affected by the other

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Features and Modules

  • Fully developed Graphical User Interface (GUI)
  • Handling of complex geometries (STL)
  • Handling of many millions of particles
  • DEM – CFD coupling to model complex multi-physics phenomena
  • Clumps (Multi-spheres), Tablets
  • Heat exchange
  • Spray modeling (coating, impregnation)
  • Post-Processing tools and support for analyzing simulation results

CONTACT

mario.torchia@insilicotrials.com

sulaiman.mohsenzada@rcpe.at

Start simulating now