ALL PRODUCTS

InSilicoTrials' Products

Hyper-accelerate drug and medical device development

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Accelerate the development
of new drugs and medical devices

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Significantly cut Research
and Development costs

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Improve safety of
new drugs and medical devices

Products for Pharma

Drug Repurposing

InSilicoDISCOVERY Suite
DISCOVERY SOLUTIONS

Drug Repurposing

Predicts putative biological targets and corresponding bioactivity of a query compound based on a large database covering a chemical space of more than 600.000 molecules and 1.000.000 activity records
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Molecular Docking

InSilicoDISCOVERY Suite
DISCOVERY SOLUTIONS

Molecular Docking

Explores the interactions between a ligand towards a biological target at the molecular level, evaluates potential target-ligand combinations and quantifies target-ligand binding affinities
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Epitopes Identification

InSilicoIDISCOVERY Suite
DISCOVERY SOLUTIONS

Epitopes Identification

Deep Learning - based. Predicts protein-protein interactions probability through 2D maps

PhysChem Properties Including BBB

InSilicoDISCOVERY Suite
DISCOVERY SOLUTIONS

Drug Repurposing

Quantifies Blood-Brain-Barrier (BBB) permeability to predict whether a compound will cross the BBB. In addition, the tools predicts a whole range of molecular PhysChem properties

Macrophages
Polarization

InSilicoDISCOVERY Suite
PRE-CLINICAL SOLUTIONS

Macrophages Polarization

Predicts phenotype changes towards M1 and M2 phenotypes (M1 and M2 scores) in an in vitro polarization experiment with customizable experimental conditions

Chemotoxicity


PRE-CLINICAL SOLUTIONS

Chemotoxicity

Evaluates a compound’s toxicological prolife by in silico assessment of the major toxicological endpoints (e.g. genotoxicity, neurotoxicity, carcinogenicity, skin irritation, etc.)

Mutagenicity


PRE-CLINICAL SOLUTIONS

Mutagenicity

Assesses a compound’s mutagenicity potential by combining two complementary quantitative structure-activity methodologies, as by ICH M7 guidelines
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Immunogenicity Risk Screen

InSilicoIMMUNO Suite
PRE-CLINICAL SOLUTIONS

Immunogenicity Risk Screen

Early immunogenecity risk screen emulates the CD4+ T-cells proliferation assay to determine the potential immunogenicity risk of new protein sequences

QT/TdP Risk Screen

InSilicoCARDIO Suite
PRE-CLINICAL SOLUTIONS

QT/TdP Risk Screen

A machine learning-based tool to predict a compound’s proarrhythmic risk using electrophysiology and machine learning
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STrhiPS

InSilicoCARDIO Suite
PRE-CLINICAL SOLUTIONS

STrhiPS

Enables in silico safety trials on a population of human-induced pluripotential stem cells
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CiPA InSilico

InSilicoCARDIO Suite
PRE-CLINICAL SOLUTIONS

QT/TdP Risk Screen

Estimates Estimation of the safety marker qNet based on up to 7 ion channels in vitro data at different concentrations, as by FDA recommendations
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ADME Properties


PRE-CLINICAL SOLUTIONS

ADME Properties

Prediction of ADME properties of a compound (absorption, distribution, metabolism and elimination)

Hemochromatosis


PRE-CLINICAL SOLUTIONS

Hemochromatosis

Predictions of the iron distribution and elimination pathway in a virtual hemochromatosis mouse based on a system-biology model

Mammary Carcinoma


PRE-CLINICAL SOLUTIONS

Mammary Carcinoma

Predictions of the immunotherapy treatment effect in a virtual population of mice with mammary carcinoma

Insulin Injection

InSilicoENDO
PRE-CLINICAL SOLUTIONS

Insulin Injection

Estimates insulin injection, skin absorption and residual volume in an injection port device over time via Computational Fluid Dynamics

PCa GnRH Agonists Simulator

InSilicoONCO Suite
CLINICAL SOLUTIONS

PCa GnRH Agonists Simulator

Enables simulations of clinical trials on a virtual population of prostate cancer patients being treated with a gonadotropin GnRH agonist
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CTx NeutroSim

InSilicoONCO Suite
CLINICAL SOLUTIONS

CTx NeutroSim

Performs In silico clinical trials to assess the neutropenic effects of a chemotherapeutic agent in a virtual population of cancer patients
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MS TreatSim

InSilicoNEURO
CLINICAL SOLUTIONS

MS TreatSim

Generates in silico trials and personalized therapeutic effect predictions in relapsing-remitting multiple sclerosis, by predicting disease activity and treatment effects in virtual patients
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Amyotrophic Lateral Sclerosis

InSilicoNEURO Suite
CLINICAL SOLUTIONS

Amyotrophic Lateral Sclerosis

Generates synthetic control arms for amyotrophic lateral sclerosis (ALS) clinical trials by predicting disease progression with virtual patients

Gaucher Disease (Types 1/3)

InSilicoNEURO Suite
CLINICAL SOLUTIONS

Gaucher Disease (Types 1/3)

Sphingolipid metabolism-based modelling to support orphan disease drug development

Parkinson’s Disease

InSilicoNEURO Suite
CLINICAL SOLUTIONS

Parkinson’s Disease

Virtual GBA-PD patients for in silico clinical trials

Systemic Lupus Erythematosus

InSilicoNEURO Suite
CLINICAL SOLUTIONS

Systemic Lupus Erythematosus

Mechanistic modelling supporting Lupus patients

Neuromyelitis Optica

InSilicoNEURO Suite
CLINICAL SOLUTIONS

Neuromyelitis Optica

Supporting NMO drug design and development

Infertility Virtual Patients

InSilicoENDO Suite
CLINICAL SOLUTIONS

Infertility Virtual Patients

Simulates the (dys)functional hormonal system guiding the menstrual cycle and treatment effects in female virtual patients in assisted reproduction clinical trials

Polycystic Ovary Syndrome

InSilicoENDO Suite
CLINICAL SOLUTIONS

Polycystic Ovary Syndrome

Simulates disease progression and treatment effects in polycystic ovary syndrome (PCOS) virtual patients

Diabetes Virtual Populations

InSilicoENDO Suite
CLINICAL SOLUTIONS

Diabetes Virtual Populations

Predicts the effect of anti-diabetic drugs and therapies in a virtual population

InSilicoVaccine Suite

InSilicoVACCINE Suite
CLINICAL SOLUTIONS

InSilicoVaccine Suite

Computational tools for every step in the design and development of a vaccine or combination therapy
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In Silico Microbiome


CLINICAL SOLUTIONS

In Silico Microbiome

Our solution leverages machine learning to uncover new drug-disease-microbe associations and hence predict indications for microbiome-based therapies

Intra-Articular Injection


CLINICAL SOLUTIONS

Intra-Articular Injection

Analyzes dissolution, diffusion and transfer of drug from intra-articular knee space to the plasma, based on physiologically-based pharmacokinetic modeling

SimTabletCoater

CMC
MANUFACTURING SOLUTIONS

SimTabletCoater

Virtually experiment tablet coating process for pharmaceutical applications, in order to establish the desired setup in terms of coater rotation speed, mass of tablets in the coater, amount and composition of the spray applied over time
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XPS

CMC
MANUFACTURING SOLUTIONS

XPS

XPS (eXtended Particle Simulation) is a highly efficient simulation solution to better understand, control and predict pharmaceutical fluid-granular processes, to enhance efficiency and improve product quality
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Products for Medtech

NONCLINICAL

InSilicoCARDIO

Standard Testing for Balloon Expandable Devices

Radial Force test in self-expandible heart valve prostheses, following ISO 5840-3 standard.​​

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NONCLINICAL

InSilicoCARDIO

SEV Radial Force Test

Enables simulations of Radial resistive force and Chronic outward force test in various types of self-expandable heart valves made in Nitinol, such as transcatheter aortic valve and transcatheter mitral valve. 

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NONCLINICAL

InSilicoCARDIO

Aorta Fluid Dynamics Tool

Tool based on a deep learning framework and computational fluid dynamic model to evaluate the flow dynamics in the thoracic aorta.

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CLINICAL

InSilicoCARDIO

Left Atrial Appendage Occluder (LAAO) Implant in Patient-Specific Anatomies

Computational fluid dynamics simulation of LAAO to improve patient selection, optimize device settings to minimize the risk of device-related thrombus and predict treatment response.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Thoracic EndoVascular Aortic Repair (TEVAR)

Computational fluid dynamics simulation of stent-graft deployment to support device optimization and preoperative planning by studying pre- and post-TEVAR hemodynamics.

CLINICAL

InSilicoCARDIO

Cardiac Arrythmia

Electrophysiological models of the heart to support prevention, diagnosis and treatment of cardiac diseases.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Catheter Lead Navigation and Ablation

Electrical and mechanical simulation of lead navigation and ablation to support device optimization and procedure planning.

NONCLINICAL

InSilicoCARDIO

Pulmonary Vein Isolation

Structural simulations to support the evaluation of procedure safety in terms of mechanical stresses, perforation risk and tissue temperature increase.

CLINICAL

InSilicoCARDIO

Flow Diverter Implantation in Cerebral Aneurysms

Structural and Computational fluid dynamics simulation of flow diverter deployment and performance in patient-specific anatomies of intracranial aneurysmatic vessel.

NONCLINICAL

InSilicoCARDIO

Drug-Eluting Stent Deployment in Arteries

Structural and drug release simulations to optimize the design of a drug-eluting stent.

NONCLINICAL

InSilicoCARDIO

Anti-Inflammatory
Drug-Eluting Pacing Leads

Drug release simulations to optimize the design of new drug-eluting collars mounted on pacing leads.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Hip Femoral Stems

Evaluation of static implant stresses and strains of device designs for Non-Modular Metallic Hip Femoral Stems.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Femoral Components

Evaluation of static implant stresses and strains of device designs for Metallic Total Knee Femoral Components under Closing Conditions.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Tibial Components

Evaluation of static implant stresses and strains of device designs for Metallic Total Knee Tibial Components.

CLINICAL

InSilicoORTHO

Virtual CranioMaxilloFacial Surgery

Patient-specific design assisted by simulations to predict the outcome of the intervention.

CLINICAL

InSilicoORTHO

Virtual High Tibial Osteotomy Surgery

Patient-specific design assisted by simulations to predict the outcome of the intervention.

CLINICAL

InSilicoORTHO

BoneStrength

Finite element simulation of hip fracture risk for osteoporosis patient.

CLINICAL

InSilicoORTHO

Muscle Atrophia Progression

Personalized musculoskeletal simulations for assessment of muscular system pathologies treatments.

CLINICAL

InSilicoNEPHRO

End Stage Kidney Failure

AI-based automated prediction of kidney failure in IgA nephropathy – automatic histologic scoring.

CLINICAL

InSilicoNEPHRO

Kidney Biopsy classification

AI-based automated clinical classification of kidney biopsy direct immunofluorescence.

CLINICAL

InSilicoNEPHRO

ADPKD Segmentator

A prognostic tool that helps to easily and quickly classify the Total Kidney Volume and Total Cyst Volume of Autosomal Dominant Polycystic Kidney Disease patients.

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NONCLINICAL

InSilico3DPRINT

InSilico3DPRINT

Digital workflow to test 3D-printed custom medical devices before manufacturing.

NONCLINICAL

InSilicoMRI

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

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NONCLINICAL

InSilicoRESPIRATORY

Drug Inhaler Combination

Computational fluid dynamics simulations to optimize the design of a spray device for drug administration.

NONCLINICAL/ CLINICAL

Drug-device combination

Combined use of different modeling strategies to simulate systems that combine drugs, devices, and/or biological products.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

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