All Products

ALL PRODUCTS

InSilicoTrials' Products

Hyper-accelerate drug and medical device development

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Accelerate the development
of new drugs and medical devices

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Significantly cut Research
and Development costs

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Improve safety of
new drugs and medical devices

Products for Pharma

DISCOVERY

Drug Repurposing

Predicts putative biological targets and corresponding bioactivity of a query compound based on a large database covering a chemical space of more than 600000 molecules and 1000000 activity records

DISCOVERY

Molecular Docking

Explores the interactions between a ligand towards a biological target at the molecular level, evaluates potential target-ligand combinations and quantifies target-ligand binding affinities

DISCOVERY

Epitopes Identification

Deep Learning-based. Predicts protein-protein interactions probability through 2D maps

DISCOVERY

PhysChem Properties

Quantifies Blood-Brain-Barrier (BBB) permeability to predict whether a compound  will cross the BBB. In addition, the tools predicts a whole range of molecular PhysChem properties

DISCOVERY

Blood Brain Barrier Penetration

Machine Learning -based. Predicts Blood Brain Barrier penetration.

NONCLINICAL

Macrophages Polarization

Predicts phenotype changes towards M1 and M2 phenotypes (M1 and M2 scores) in an in vitro polarization experiment with customizable experimental conditions

NONCLINICAL

Chemotoxicity

Evaluates a compound’s  toxicological prolife by in silico assessment of the major toxicological endpoints (e.g. genotoxicity, neurotoxicity, carcinogenicity, skin irritation, etc.)

NONCLINICAL

Mutagenicity

Assesses a compound’s mutagenicity potential by combining two complementary quantitative structure-activity methodologies, as by ICH M7 guidelines

NONCLINICAL

InSilicoIMMUNO

Immunogenicity Risk Screen

Early immunogenecity risk screen  emulates the CD4+ T-cells proliferation assay to determine the potential immunogenicity risk of new protein sequences.

NONCLINICAL

InSilicoCARDIO 

QT/TdP Risk Screen

A machine learning-based tool to predict a compound’s proarrhythmic risk using electrophysiology and machine learning.

NONCLINICAL

InSilicoCARDIO 

STrhiPS

Enables in silico safety trials on a population of human-induced pluripotential stem cells

NONCLINICAL

InSilicoCARDIO 

CiPA InSilico

Estimates Estimation of the safety marker qNet based on up to 7 ion channels in vitro data at different concentrations, as by FDA recommendations.

NONCLINICAL

ADME Properties

Prediction of ADME properties of a compound (absorption, distribution, metabolism and elimination)

NONCLINICAL

Hemochromatosis

Predictions of the iron distribution and elimination pathway in a virtual hemochromatosis mouse based on a system-biology model.

NONCLINICAL

InSilicoONCO

Mammary Carcinoma

Predictions of the immunotherapy treatment effect in a virtual population of mice with mammary carcinoma

NONCLINICAL

InSilicoENDO

Insulin Injection

Estimates insulin injection, skin absorption and residual volume in an injection port device over time via Computational Fluid Dynamics.

CLINICAL

InSilicoONCO

PCa GnRH Agonists Simulator

Enables simulations of clinical trials on a virtual population of prostate cancer patients being treated with a gonadotropin GnRH agonist.

CLINICAL

InSilicoONCO

CTx NeutroSim

Performs In silico clinical trials to assess the neutropenic effects of a chemotherapeutic agent in a virtual population of cancer patients.

CLINICAL

InSilicoNEURO 

MS TreatSim

Generates in silico trials and personalized therapeutic effect predictions in relapsing-remitting multiple sclerosis, by predicting disease activity and treatment effects in virtual patients.

CLINICAL

InSilicoNEURO

Amyotrophic Lateral Sclerosis

Generates synthetic control arms for amyotrophic lateral sclerosis (ALS) clinical trials by predicting disease progression with virtual patients.

CLINICAL

InSilicoENDO

Infertility Virtual Patients

Simulates the (dys)functional hormonal system guiding the menstrual cycle and treatment effects in female virtual patients in assisted reproduction clinical trials

CLINICAL

InSilicoENDO

Polycystic Ovary Syndrome

Simulates disease progression and treatment effects in polycystic ovary syndrome (PCOS) virtual patients.

CLINICAL

InSilicoDIABETES

Diabetes Virtual Populations

Predicts the effect of anti-diabetic drugs and therapies in a virtual population.

CLINICAL

InSilicoVACCINE

InSilicoVaccine Suite

Computational tools for every step in the design and development of a vaccine or combination therapy.

CLINICAL

REUMATOLOGY

Intra-Articular Injection

Analyzes dissolution, diffusion and transfer of drug from intra-articular knee space to the plasma, based on physiologically-based pharmacokinetic modeling.

MANUFACTURING

CMC

SimTabletCoater

Virtually experiment tablet coating process for pharmaceutical applications, in order to establish the desired setup in terms of coater rotation speed, mass of tablets in the coater, amount and composition of the spray applied over time.

MANUFACTURING

CMC

XPS

XPS (eXtended Particle Simulation) is a highly efficient simulation solution to better understand, control and predict pharmaceutical fluid-granular processes, to enhance efficiency and improve product quality.

Products for Medtech

NONCLINICAL

InSilicoCARDIO

Standard Testing for Balloon Expandable Devices

A suite comprehensive of various in silico reproductions of standard tests to assess the performance of balloon-expandable stents or heart valve substitutes.

NONCLINICAL

InSilicoCARDIO

SEV Radial Force Test

In silico reproduction of Radial Force test in self-expandible heart valve prostheses, following ISO 5840-3 standard.​​

NONCLINICAL

InSilicoCARDIO

Aorta Fluid Dynamics Tool

Tool based on a deep learning framework and computational fluid dynamics model to evaluate the flow dynamics in the thoracic aorta.

CLINICAL

InSilicoCARDIO

Left Atrial Appendage Occluder (LAAO) Implant in Patient-Specific Anatomies

Computational fluid dynamics simulation of LAAO to improve patient selection, optimize device settings to minimize the risk of device-related thrombus and predict treatment response.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Thoracic EndoVascular Aortic Repair (TEVAR)

Computational fluid dynamics simulation of stent-graft deployment to support device optimization and preoperative planning by studying pre- and post-TEVAR hemodynamics.

CLINICAL

InSilicoCARDIO

Cardiac Arrythmia

Electrophysiological models of the heart to support prevention, diagnosis and treatment of cardiac diseases.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Catheter Lead Navigation and Ablation

Electrical and mechanical simulation of lead navigation and ablation to support device optimization and procedure planning.

NONCLINICAL

InSilicoCARDIO

Pulmonary Vein Isolation

Structural simulations to support the evaluation of procedure safety in terms of mechanical stresses, perforation risk and tissue temperature increase.

CLINICAL

InSilicoCARDIO

Flow Diverter Implantation in Cerebral Aneurysms

Structural and Computational fluid dynamics simulation of flow diverter deployment and performance in patient-specific anatomies of intracranial aneurysmatic vessel.

NONCLINICAL

InSilicoCARDIO

Drug-Eluting Stent Deployment in Arteries

Structural and drug release simulations to optimize the design of a drug-eluting stent.

NONCLINICAL

InSilicoCARDIO

Anti-Inflammatory
Drug-Eluting Pacing Leads

Drug release simulations to optimize the design of new drug-eluting collars mounted on pacing leads.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Hip Femoral Stems

Evaluation of static implant stresses and strains of device designs for non-modular metallic hip femoral stems, following the ASTM F2996-20 standard.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Femoral Components

Evaluation of static implant stresses and strains of device designs for metallic total knee femoral components, following the ASTM F3161-16 standard.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Tibial Components

Evaluation of static implant stresses and strains of device designs for Metallic Total Knee Tibial Components.

CLINICAL

InSilicoORTHO

Virtual CranioMaxilloFacial Surgery

Patient-specific design assisted by simulations to predict the outcome of the intervention.

CLINICAL

InSilicoNEPHRO

End Stage Kidney Failure

Automated prediction and histologic scoring kidney failure in IgA nephropathy, also known as Berger’s disease nephropathy, based on artificial intelligence.

CLINICAL

InSilicoNEPHRO

Kidney Biopsy Classification

Automated clinical classification of kidney biopsy from direct immunofluorescence, based on artificial intelligence.

CLINICAL

InSilicoNEPHRO

ADPKD Segmentator

Fast and accurate estimation of Autosomal Dominant Polycystic Kidney Disease risk classification and progression, based on automated kidney and cysts segmentation from MRI data.

NONCLINICAL

InSilico3DPRINT

InSilico3DPRINT

Digital workflow to virtually assess safety and performance of 3D-printed custom medical devices before prototyping and manufacturing.

NONCLINICAL

InSilicoMRI

NuMRis

Assessment of radiofrequency-induced heating on or near passive implants during magnetic resonance imaging, following the ASTM F2182-19e2 standard

NONCLINICAL

InSilicoRESPIRATORY

Drug Inhaler Combination

Computational fluid dynamics simulations to optimize the design of a spray device for drug administration.

NONCLINICAL/ CLINICAL

Drug-device Combination

Combined use of different modeling strategies to simulate systems that combine drugs, devices, and/or biological products.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

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