SOLUTIONS FOR MEDTECH

Modeling and Simulation to improve medical device design & development

Modeling and simulation (M&S) approaches are playing an increasingly important role in the design and development of new medical products for assessment of their safety and/or efficacy, and furthermore in supporting regulatory submission and decisions.

In silico techniques can be applied to different phases of medical device design, from concept through verification and certification, to make predictions about mechanical performance, durability and resistance, deployment effects and interaction with human anatomy

Accelerate the development
of new medical devices

Significantly cut Research
and Development costs

Improve the safety of
medical devices

NONCLINICAL

InSilicoCARDIO

Standard Testing for Balloon Expandable Devices

A suite comprehensive of various in silico reproductions of standard tests to assess the performance of balloon-expandable stents or heart valve substitutes.

NONCLINICAL

InSilicoCARDIO

SEV Radial Force Test

In silico reproduction of Radial Force test in self-expandible heart valve prostheses, following ISO 5840-3 standard.

NONCLINICAL

InSilicoCARDIO

Aorta Fluid Dynamics Tool

Tool based on a deep learning framework and computational fluid dynamics model to evaluate the flow dynamics in the thoracic aorta.

CLINICAL

InSilicoCARDIO

Left Atrial Appendage Occluder (LAAO) Implant in Patient-Specific Anatomies

Computational fluid dynamics simulation of LAAO to improve patient selection, optimize device settings to minimize the risk of device-related thrombus and predict treatment response.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Thoracic EndoVascular Aortic Repair (TEVAR)

Computational fluid dynamics simulation of stent-graft deployment to support device optimization and preoperative planning by studying pre- and post-TEVAR hemodynamics.

CLINICAL

InSilicoCARDIO

Cardiac Arrythmia

Electrophysiological models of the heart to support prevention, diagnosis and treatment of cardiac diseases.

NONCLINICAL/ CLINICAL

InSilicoCARDIO

Catheter Lead Navigation and Ablation

Electrical and mechanical simulation of lead navigation and ablation to support device optimization and procedure planning.

NONCLINICAL

InSilicoCARDIO

Pulmonary Vein Isolation

Structural simulations to support the evaluation of procedure safety in terms of mechanical stresses, perforation risk and tissue temperature increase.

CLINICAL

InSilicoCARDIO

Flow Diverter Implantation in Cerebral Aneurysms

Structural and Computational fluid dynamics simulation of flow diverter deployment and performance in patient-specific anatomies of intracranial aneurysmatic vessel.

NONCLINICAL

InSilicoCARDIO

Drug-Eluting Stent Deployment in Arteries

Structural and drug release simulations to optimize the design of a drug-eluting stent.

NONCLINICAL

InSilicoCARDIO

Anti-Inflammatory
Drug-Eluting Pacing Leads

Drug release simulations to optimize the design of new drug-eluting collars mounted on pacing leads.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Hip Femoral Stems

Evaluation of static implant stresses and strains of device designs for non-modular metallic hip femoral stems, following the ASTM F2996-20 standard.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Femoral Components

Evaluation of static implant stresses and strains of device designs for metallic total knee femoral components, following the ASTM F3161-16 standard.

NONCLINICAL

InSilicoORTHO

In Silico Standard Testing of Total Knee Tibial Components

Evaluation of static implant stresses and strains of device designs for Metallic Total Knee Tibial Components.

CLINICAL

InSilicoORTHO

Virtual CranioMaxilloFacial Surgery

Patient-specific design assisted by simulations to predict the outcome of the intervention.

CLINICAL

InSilicoNEPHRO

End Stage Kidney Failure

Automated prediction and histologic scoring kidney failure in IgA nephropathy, also known as Berger’s disease nephropathy, based on artificial intelligence.

CLINICAL

InSilicoNEPHRO

Kidney Biopsy Classification

Automated clinical classification of kidney biopsy from direct immunofluorescence, based on artificial intelligence.

CLINICAL

InSilicoNEPHRO

ADPKD Segmentator

Fast and accurate estimation of Autosomal Dominant Polycystic Kidney Disease risk classification and progression, based on automated kidney and cysts segmentation from MRI data.

NONCLINICAL

InSilico3DPRINT

InSilico3DPRINT

Digital workflow to virtually assess safety and performance of 3D-printed custom medical devices before prototyping and manufacturing.

NONCLINICAL

InSilicoMRI

NuMRis

Assessment of radiofrequency-induced heating on or near passive implants during magnetic resonance imaging, following the ASTM F2182-19e2 standard

NONCLINICAL

InSilicoRESPIRATORY

Drug Inhaler Combination

Computational fluid dynamics simulations to optimize the design of a spray device for drug administration.

NONCLINICAL/ CLINICAL

Drug-device Combination

Combined use of different modeling strategies to simulate systems that combine drugs, devices, and/or biological products.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

NuMRis

Assessment of radiofrequency-induced heating of passive devices following the ASTM F2182-19e2 standard.

Modeling and Simulation to improve medical device design & development

Accelerate the development of new medical devices

Significantly cut Research and Development costs

Improve the safety of medical devices

Standard Testing for Balloon Expandable Devices

SEV Radial Force Test

Aorta Fluid Dynamics Tool

Left Atrial Appendage Occluder (LAAO) Implant in Patient-Specific Anatomies

Thoracic EndoVascular Aortic Repair (TEVAR)

Cardiac Arrythmia

Catheter Lead Navigation and Ablation

Pulmonary Vein Isolation

Flow Diverter Implantation in Cerebral Aneurysms

Drug-Eluting Stent Deployment in Arteries

Anti-Inflammatory Drug-Eluting Pacing Leads

In Silico Standard Testing of Hip Femoral Stems

In Silico Standard Testing of Total Knee Femoral Components

In Silico Standard Testing of Total Knee Tibial Components

Virtual CranioMaxilloFacial Surgery

End Stage Kidney Failure

Kidney Biopsy Classification

ADPKD Segmentator

InSilico3DPRINT

NuMRis

Drug Inhaler Combination

Drug-device Combination

NuMRis

NuMRis

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Accelerate the development
of new medical devices

Significantly cut Research
and Development costs

Improve the safety of
medical devices

Anti-Inflammatory
Drug-Eluting Pacing Leads